September 25, 2025Open Access

Acute Promyelocytic Leukemia: Pathophysiology, Diagnosis and Clinical Management

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This review highlights diagnosis and management of acute promyelocytic leukemia, suggesting critical interventions for improving outcomes.

Acute promyelocytic leukemia is characterized by the PML-RARα fusion gene, influencing leukemogenesis and coagulopathy.
Diagnosis integrates immunophenotyping, cytomorphology, coagulation studies, and molecular confirmation for accurate detection.
Prompt initiation of all-trans-retinoic acid is crucial to manage bleeding risk in acute promyelocytic leukemia patients.
Early recognition and targeted therapy have significantly improved curability and outcomes in acute promyelocytic leukemia.

Abddaoui et al. (2025) studied this question.

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This review highlights diagnosis and management of acute promyelocytic leukemia, suggesting critical interventions for improving outcomes.