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September 5, 2025Clinical and Experimental MedicineOpen Access

Identification and validation of prognostic genes associated with mitochondrial nuclear genes in gastric cancer

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Authors

CFCong FuLSLin SunXZXiaoyue Zhou

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Overview

Analysis reveals key prognostic genes in gastric cancer, suggesting links to immune infiltration and drug sensitivity.

Key Points

  • Three prognostic genes, ATP8A2, COX15, and TARS2, were identified as significant markers in gastric cancer outcomes.
  • The risk model exhibited excellent predictive performance and correlated with immune cells like T cells and B cells.
  • Differential expression analysis showed downregulation of ATP8A2 and upregulation of COX15 and TARS2 in gastric cancer samples.
  • Drug sensitivity analysis indicated significant differences in response between high-risk and low-risk groups for various treatments.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477b9c0https://doi.org/10.1007/s10238-025-01844-3
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  5. 5Integrated Analysis of Glycosylation and Inflammation-Related Genes for Prognostic Risk Modeling and Immunotherapy Response Prediction in Gastric Cancer2025