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August 1, 2025OncoTargets and TherapyOpen Access

Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis

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Authors

WQWei QiuKZKe ZhangWHWei Hu

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Overview

Bioinformatics analysis identifies eight migrasome-related genes influencing outcomes in gastric cancer, suggesting new therapeutic targets.

Key Points

  • Eight migrasome-related genes showed significant prognostic value in gastric cancer, indicating potential for personalized medicine.
  • The risk-scoring model achieved an AUC greater than 0.6, demonstrating robust predictive performance in both training and validation cohorts.
  • Gene set enrichment analysis indicated significant pathways, especially the TGF-β signaling pathway, contributing to immune regulation.
  • Experimental validation confirmed differential expression of BMP1, LEFTY1, and TGFB2, emphasizing their roles in gastric cancer pathology.

Cite This Study

Qiu et al. (2025) studied this question.

synapsesocial.com/papers/68af2683cf1dd9ea359e18dahttps://doi.org/10.2147/ott.s528050
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