September 5, 2025

Polydatin attenuates sodium fluoride-induced oxidative and inflammatory damage in rats

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Rats treated with polydatin show reduced oxidative stress and inflammation, indicating protective effects.

Polydatin administration significantly reduced oxidative stress markers in rats exposed to sodium fluoride.
Sodium fluoride exposure elevated liver enzyme levels and inflammatory gene expression, indicating tissue damage.
Histopathological evaluations demonstrated that polydatin mitigated organ damage in the liver, brain, and kidneys.
The protective effects of polydatin were observed in a dose-dependent manner across various biochemical parameters.

Gunduz et al. (2025) studied this question.

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