September 10, 2025Open Life SciencesOpen Access

Polydatin prevents cholesterol gallstone formation by regulating cholesterol metabolism via PPAR-γ signaling

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Discussion

In vivo analysis revealed polydatin reduces cholesterol gallstone formation in mice, suggesting mechanisms via PPAR-γ signaling.

Polydatin significantly reduced cholesterol gallstone formation and improved lipid profiles in serum.
After 8 weeks, mice treated with polydatin showed fewer pathological alterations in gallbladder and liver tissues.
In vitro studies demonstrated that polydatin inhibited inflammatory cytokine release in human biliary epithelial cells.
Regulation of cholesterol metabolism-related genes and activation of the PPAR-γ signaling pathway were observed.

Li et al. (2025) studied this question.

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