This analysis identifies key genes and mechanisms of proanthocyanidins in mitigating fluoride-induced liver injury, suggesting network pharmacology as a useful approach.
Key Points
Proanthocyanidins effectively alleviate fluoride-induced liver injury, potentially via the mTOR signaling pathway.
Network pharmacological analysis revealed 96 key genes involved in the therapeutic effects of proanthocyanidins.
Animal experiments demonstrated that proanthocyanidins regulate protein expression levels linked to liver injury, affecting the mTOR pathway.
The study highlights the protective effects of proanthocyanidins against hepatic damage, presenting significant therapeutic possibilities.