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September 5, 2025Journal of Contemporary Medical PracticeOpen Access

Exploration of the Mechanism of the Method of Warming and Tonifying the Spleen and Kidney in Treating Diarrhea-predominant Irritable Bowel Syndrome Based on the “Brain-Gut Axis” Theory

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Authors

YWYubin WangJHJianping HuiPFPo‐Hao Feng

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Overview

Observational analysis reveals how TCM interventions alter brain-gut axis function in IBS-D, indicating potential symptom relief.

Key Points

  • The TCM method for warming and tonifying the spleen and kidney alleviates symptoms of IBS-D.
  • Significantly, it modulates the brain-gut axis function, impacting multiple neuropeptide levels.
  • Using rat models, the treatment regulates the signaling pathways related to IBS-D and reduces hypersensitivity.
  • This approach emphasizes the relevance of TCM in managing diarrhea and abdominal pain in IBS-D patients.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23965b210217d6477b433https://doi.org/10.53469/jcmp.2025.07(08).21
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Also Consider

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  3. 3The Role of Ganyu in Formation of Liver Depression and Spleen Deficiency Syndrome: Analysis From Gut Microbiota2025 · 1 citations
  4. 4Changji’an formula alleviates visceral hypersensitivity of a post-inflammatory IBS-D mouse model via NGF/TrkA signaling pathway2025
  5. 5Commentary: One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis2025 · 1 citations