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September 16, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Commentary: One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis

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Authors

JYJing YaoJLJiang LinYXYichuan Xv

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Overview

Commentary finds Sishen Pill reduces harmful gut bacteria and improves enzyme activity in diarrhea linked to kidney yang deficiency syndrome.

Key Points

  • Sishen Pill may alleviate diarrhea by reducing harmful gut bacteria and modulating enzyme activities.
  • The findings indicate potential regulation of energy metabolism and enhancement of gastrointestinal function.
  • Future studies should incorporate germ-free models to distinguish host from microbiota-derived enzyme activities.
  • Innovative approaches connecting traditional Chinese medicine and modern science show promise for therapeutic advancements.

Cite This Study

Yao et al. (2025) studied this question.

synapsesocial.com/papers/68d42328713b0b5dfea6af1chttps://doi.org/10.3389/fcimb.2025.1690941
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis.2025
  2. 2Effect of Sodium Butyrate and Sishen Pill Combination on Diarrhea with Kidney-Yang Deficiency Syndrome Was Associated with Intestinal Mucosal Microbiota and Immune Barrier2025
  3. 3Commentary: Wuling powder ameliorates diarrhea-predominant irritable bowel syndrome in mice by modulating gut mucosal microbiota and alleviating intestinal inflammation2025
  4. 4Exploration of the Mechanism of the Method of Warming and Tonifying the Spleen and Kidney in Treating Diarrhea-predominant Irritable Bowel Syndrome Based on the “Brain-Gut Axis” Theory2025
  5. 5Unraveling the mysteries of the gut-kidney axis: the protective role of traditional Chinese medicine in chronic kidney disease2025 · 6 citations