September 10, 2025Neuroreport

Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Observational analysis revealed alterations in FOXO3 and inflammation in microglia, suggesting USP30's critical role in SAH progression.

Downregulation of FOXO3 inhibits inflammation and pyroptosis in microglia, leading to potential therapeutic benefits.
USP30 knockdown reduces inflammatory responses in OxyHb-induced microglia, showing its role in SAH pathology.
Analysis employed Western blot, ELISA, and cell counting assays to investigate FOXO3 and inflammation dynamics.
Findings highlight USP30's involvement in FOXO3 stabilization through deubiquitination, contributing to disease progression.

Zhang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark