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September 10, 2025Frontiers in Veterinary ScienceOpen Access

Potential mechanisms of zinc sulfate in inhibiting porcine reproductive and respiratory syndrome virus replication: attenuation of oxidative stress, inflammatory response, and apoptosis

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Authors

HYHuizhen YangCZC. ZhangQLQianfan Li

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Overview

Experimental validation reveals zinc sulfate reduces PRRSV replication via oxidative stress and inflammatory response modulation.

Key Points

  • Zinc sulfate significantly suppressed porcine reproductive and respiratory syndrome virus replication.
  • Compared to the PRRSV-infected group, treatments resulted in 50 downregulated and 14 upregulated targets.
  • Oxidative stress levels were significantly diminished, while enzymatic activities of superoxide dismutase and catalase increased.
  • Zinc sulfate notably attenuated apoptosis in infected cells, validating its protective role against PRRSV.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786200https://doi.org/10.3389/fvets.2025.1663508
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