Acute Non-Promyelocytic Leukemia with Complex Karyotype and Novel t (15;17) (q21; p11.2)/B2M: RARA Fusion: A Case Report

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Case report reveals a complex karyotype in AML harboring t(15;17) and B2M-RARA fusion, indicating unique management.

Novel t(15;17)(q21;p11.2) and B2M-RARA fusion found in acute myeloid leukemia highlights distinct pathology.
Genetic assessment revealed additional complex abnormalities including TP53 mutation and negative results for PML-RARA.
The patient was effectively managed using a combination of hypomethylating agents and venetoclax, showing promising results.
This case underscores the need for careful evaluation of cytogenetic features to differentiate from acute promyelocytic leukemia.

Kachhwaha et al. (2025) studied this question.

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