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September 5, 2025Current Cancer Drug Targets

SOX9 Promotes Breast Cancer Progression via the EGFR/STAT3 Signaling Axis

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Authors

CZChunrui ZhangNLNa LiFXFei Xue

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Overview

This study reveals SOX9's role in promoting migration and invasion in breast cancer, suggesting a vital link with the EGFR/STAT3 pathway.

Key Points

  • SOX9 promotes breast cancer cell proliferation, migration, and invasion through the EGFR/STAT3 signaling axis.
  • Modulation of SOX9 in cell lines demonstrated significant changes in oncogenic phenotypes, indicating its critical role.
  • Integrating functional assays and bioinformatics analyses identified a direct connection between SOX9 and EGFR/STAT3 activation.
  • Understanding SOX9's mechanisms in breast cancer highlights its potential as a prognostic biomarker and therapeutic target.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a33fhttps://doi.org/10.2174/0115680096369386250717220332
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SOX9: an important factor in regulating breast cancer2025
  2. 2SOX11 Is Regulated by EGFR-STAT3 and Promotes Epithelial–Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma2026
  3. 3SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer2025
  4. 4SOX10 Regulates Melanoma Metastasis Through the IRF1-ITGA3/EphA2-FAK Pathway.2025 · 2 citations
  5. 5CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway2025