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August 18, 2025European journal of medical researchOpen Access

SOX9: an important factor in regulating breast cancer

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Authors

YWYaru WangJCJuhang ChuLHLuyao Huang

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Overview

Review explores sox9's role in tumor growth and chemotherapy resistance in breast cancer, suggesting therapeutic targeting.

Key Points

  • Overexpression of sox9 is frequently found in breast cancer, indicating its significant role in tumor development and progression.
  • SOX9 is a transcription factor involved in tumor initiation, proliferation, migration, and chemotherapy resistance in cancer.
  • This review analyzes recent developments in the understanding of sox9's structure and function in breast cancer's pathogenesis.
  • Targeting sox9 may improve therapeutic outcomes in breast cancer, highlighting its potential as a treatment strategy.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af2d83cf1dd9ea359e5bf1https://doi.org/10.1186/s40001-025-02730-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SOX9 Promotes Breast Cancer Progression via the EGFR/STAT3 Signaling Axis2025 · 1 citations
  2. 2SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer2025
  3. 3SOX9 Is a Key Factor for the Postnatal Maturation of the Intrahepatic Bile Duct Network2025
  4. 4SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer2025 · 2 citations
  5. 5A cytotoxic gene therapy targeting SOX9-positive therapy-resistant medulloblastoma2025