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September 5, 2025Oftalmologicheskii ZhurnalOpen Access

Morphometric analysis of retinal structural components in СВА/С57 mice in experimental diabetes mellitus

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Authors

ODOleksandra DorokhovaLSL. I. SamoilenkoEME. V. Maltsev

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Overview

Observational analysis revealed retinal thickness changes in СВА/С57 mice with diabetes mellitus, indicating potential structural impacts.

Key Points

  • Diabetic СВА/С57 mice showed increased total retinal thickness to 227.8 ± 6.2 µm compared to 197.2 ± 6.32 µm in controls.
  • Hematoxylin-and-eosin stained retinal layers showed significant thickening in the inner layers due to edema (p < 0.01).
  • Retinal morphometric analysis did not reveal neurodegenerative changes in diabetic models, indicating limitations in this mouse model.
  • The study examined structural changes in various retinal layers, contributing to the understanding of diabetes effects on retinal health.

Cite This Study

Dorokhova et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a2b7https://doi.org/10.31288/oftalmolzh20254954
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