Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Nature CommunicationsOpen Access

Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

BWBinbin WangRSRobert Saddawi‐KonefkaLCLauren Clubb

Discussion

Loading...

Member takes

Overview

Longitudinal analysis identifies ICB response biomarkers in head and neck cancer, suggesting broader applications.

Key Points

  • Dynamic immune features may predict immune checkpoint blockade response in head and neck cancer.
  • Early on-treatment immune changes included a significant expansion of effector memory T and B cell populations.
  • Multi-omic approaches were utilized to assess immune responses in both murine models and human cohorts.
  • These findings highlight the potential for non-invasive biomarkers to enhance immunotherapy strategies across cancer types.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d07dhttps://doi.org/10.1038/s41467-025-63538-4
View Full Paper
Ask AI
Bookmark
Share