September 5, 2025Environment InternationalOpen Access

Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood

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Nested case-control study investigates PFAS exposure impacts on TGCC risk, highlighting endocrine disruptor concerns.

Limited evidence shows no strong association between fetal PFAS exposure and testicular germ cell cancer risk.
Hazard ratios for perfluoroalkyl sulfonic acids suggest modestly increased TGCC risk with higher concentrations.
A nested case-control approach analyzed maternal serum from over 100,000 women, assessing PFAS levels and TGCC outcomes.
Findings indicate higher risk for seminomas compared to nonseminomas, underlining the need for further in-depth study.

Uldbjerg et al. (2025) studied this question.

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