September 23, 2025Open Access

Exposure to Per- and Polyfluoroalkyl Substances and Risk of Reproductive System Cancers: A Systematic Review and Meta-Analysis

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Discussion

Systematic review finds no significant link between PFAS exposure and reproductive cancers, indicating potential risks for males.

Serum exposure to PFAS did not show significant association with female reproductive cancers, highlighting safety concerns.
Pooled adjusted odds ratios reveal PFOS is marginally associated with an increased risk of male reproductive cancers.
Sensitivity analyses indicate PFNA exposure correlates positively with female reproductive cancers, suggesting further investigation.
Case-control studies included in the analysis indicate the complex relationship between PFAS and reproductive health outcomes.

Liu et al. (2025) studied this question.

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