Safety Evaluation of Sub-acute and Acute Oral Treatment with Aqueous Extract and Methanol Fraction of Aloe barbadensis (Aloe vera) Leaves in Wistar Rats
This study reveals no significant adverse effects in Wistar rats for acute and subacute toxicity of aloe barbadensis, suggesting its therapeutic potential.
Key Points
Continuous treatment with the methanol fraction at 750 mg/kg showed potential organ toxicity after 28 days.
Both the acute and subacute toxicity were assessed with doses of 2000, 5000, and 6000 mg/kg, plus daily doses for 28 days.
No significant adverse effects were found in biochemical or haematological parameters (p > 0.05) across all doses.
This research highlights the need for regulation of extract doses and suggests future long-term chronic toxicity studies.