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September 5, 2025Journal of Pharmacy & Pharmacognosy ResearchOpen Access

Quercetin-3'-O-glucoside and delphinidin-3-O-sambubioside from Hibiscus sabdariffa Linn.: A molecular docking study against pathogen-associated molecular patterns and Toll-like receptors

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Authors

NPNurul Aisyah Rizki PutrantiAPAdya PramusitaRRRini Devijаnti Ridwаn

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Overview

Molecular docking reveals strong affinities of flavonoids for Toll-like receptors and bacterial pathogens, suggesting their potential as drug candidates.

Key Points

  • Flavonoids quercetin-3'-O-glucoside and delphinidin-3-O-sambubioside exhibited strong binding affinities in docking studies.
  • The study found that these compounds have potential antibacterial and immunomodulatory properties against bacterial pathogens.
  • Molecular docking simulations highlighted their effectiveness at inhibiting key virulence factors associated with bacterial infections.
  • Promising therapeutic candidates for adjunctive treatment of Gram-negative bacterial infections were identified in this research.

Cite This Study

Putranti et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64778c4bhttps://doi.org/10.56499/jppres25.2361_13.s1.303
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