August 16, 2025Open Access

Peroxisome Proliferator-Activated Receptor Family of Lipid-Activated Nuclear Receptors Alpha Silencing Promotes Oxidative Stress and Hypertrophic Phenotype in Rat Cardiac Cells

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In vitro model reveals PPARα silencing induces oxidative stress and a hypertrophic phenotype, indicating potential therapeutic avenues with Ebselen.

Silencing PPARα resulted in a hypertrophic phenotype in cardiac cells, indicating its role in lipid metabolism and oxidative stress.
Key metrics include increased NPPB and decreased FBXO32 expression, alongside alterations in miRNAs, pointing to a complex regulatory mechanism.
Analysis of cardiac hypertrophy used stable silencing of the PPARA gene in H9c2 rat cardiomyoblasts, a relevant in vitro model to study cardiac function.
Findings support the potential use of Ebselen for reversing the hypertrophic phenotype, suggesting avenues for treating cardiac conditions.

Bianchi et al. (2025) studied this question.

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In vitro model reveals PPARα silencing induces oxidative stress and a hypertrophic phenotype, indicating potential therapeutic avenues with Ebselen.