September 12, 2025Open Access

Nutrient-Sensing Nuclear Receptor PPARα Controls Liver Proteostasis

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Discussion

Multi-omics analysis reveals PPARα controls protein synthesis and degradation in the liver, suggesting a role beyond metabolism.

PPARα activation enhances proteasome activity while attenuating hepatic protein synthesis.
Chronic PPARα activation reduces secretome gene expression and serum protein levels.
The phosphorylation of eIF2α is increased, indicating impaired protein synthesis mechanisms.
Findings suggest that PPARα has a broader role in regulating liver proteostasis and conserving energy.

Kim et al. (2025) studied this question.

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