August 25, 2025AJP Cell PhysiologyOpen Access

Oxidized Phosphatidylcholines Activate NOX1-Mediated Oxidative Stress Response and Shift Glucose Metabolism in Cardiac Cells

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Discussion

Treatment with oxidized phosphatidylcholines alters metabolic pathways in cardiac cells, indicating a role in oxidative stress.

Oxidized phosphatidylcholines induce significant transcriptional changes in metabolism and redox processes.
Key evidence includes the upregulation of genes regulated by the Nrf2 pathway in H9c2 cells after OxPAPC treatment.
Observational analysis of cardiac myoblasts exposed to oxidized phosphatidylcholines revealed changes in energy production pathways leading to decreased ATP.
Findings suggest that Nox1 may mediate oxidative stress-induced cellular damage in cardiometabolic syndrome.

Licznerska et al. (2025) studied this question.

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