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August 16, 2025MetabolitesOpen Access

Triglyceride–Glucose Index and New-Onset Type 2 Diabetes Mellitus in Middle-Aged Men

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Authors

LDLanfranco D’EliaDRDomenico RendinaRIRoberto Iacone

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Overview

Analysis reveals TyG index significantly predicts new-onset T2DM in men, suggesting its value in cardio-metabolic risk assessment.

Key Points

  • A baseline triglyceride-glucose index above 4.88 significantly increases the risk of developing type 2 diabetes mellitus.
  • The analysis involved 789 adult men without prior type 2 diabetes, using receiver operating characteristic curve analysis to find optimal thresholds.
  • Data from the Olivetti Heart Study demonstrates a strong correlation between triglyceride-glucose index and incidence of diabetes.
  • These findings imply that the TyG index could be a useful, non-invasive tool for early diabetes risk assessment.

Cite This Study

D’Elia et al. (2025) studied this question.

synapsesocial.com/papers/68c235fdb210217d64772c1fhttps://doi.org/10.3390/metabo15080537
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Triglyceride-glucose index, HOmeostatic Model Assessment index, and new-onset hypertension in middle-aged men2025
  2. 2Dose-response relationship between the triglyceride-glucose index and metabolic syndrome risk in patients with type 2 diabetes: a cross-sectional analysis of 1,560 cases2025 · 1 citations
  3. 3The triglyceride-glucose index as a surrogate marker of insulin resistance for predicting peripheral vascular complications in patients with type 2 diabetes: A retrospective analysis2026
  4. 4High triglyceride-glucose index is associated with diabetes mellitus in people with HIV in Southwest China: a 13-year retrospective longitudinal cohort study2025 · 2 citations
  5. 5The triglyceride-glucose index as a predictor of cardiovascular abnormalities in obese patients2025