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August 12, 2025Therapeutic Advances in Medical OncologyOpen Access

Immune landscape and TAM density in endometrial cancer: implications for immune checkpoint inhibitors efficacy

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Authors

OSOlivia Le SauxRSRenaud SabatierITIsabelle Treilleux

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Overview

Observational analysis shows distinct immune patterns in endometrial cancer, highlighting macrophage density's role in predicting treatment response.

Key Points

  • A significant correlation was found between low tumor-associated macrophage density and response to immune checkpoint inhibitors.
  • Patients with MMRd/MSI-H tumors had higher densities of CD8 T effector cells compared to MMRp/MSS tumors, suggesting immune cooperation.
  • Analysis involved 33 advanced endometrial cancer patients treated with immune checkpoint inhibitors across six centers.
  • Distinct immune infiltrate patterns were identified in MMRd/MSI-H and MMRp/MSS tumors, emphasizing the importance of tumor immune microenvironment.

Cite This Study

Saux et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d647713c8https://doi.org/10.1177/17588359251347364
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and Molecular Differences Suggest Different Responses to Immune Checkpoint Inhibitors in Microsatellite-Stable Solid Tumors with High Tumor Mutational Burden2025
  2. 2Immune checkpoint inhibitors or targeted therapy by mismatch repair status in endometrial cancer: a meta-analysis.2025 · 3 citations
  3. 3The immune microenvironment in endometrial carcinoma: mechanisms and therapeutic targeting2025
  4. 4Analysis of T Cell Subsets Using Multiplex Immunohistochemistry and Clinical Outcomes of Immune Checkpoint Inhibitors in Advanced Gastric Cancer Patients2025
  5. 5Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment2025 · 9 citations