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September 12, 2025Cancer Research and TreatmentOpen Access

Analysis of T Cell Subsets Using Multiplex Immunohistochemistry and Clinical Outcomes of Immune Checkpoint Inhibitors in Advanced Gastric Cancer Patients

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Authors

TKTae-Yong KimJYJeesun YoonDLDae-Won Lee

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Overview

Analyzing T cell subsets impacts clinical outcomes in gastric cancer, suggesting immunotherapy pathways.

Key Points

  • A high density of cytotoxic T-cells is linked to improved overall survival in gastric cancer patients.
  • Patients with favorable T-cell ratios showed better tumor responses and longer overall survival rates.
  • Multiplex immunohistochemistry effectively assesses T-cell subsets in archival gastric tumor tissue.
  • The study indicates that specific T-cell populations may enhance the efficacy of immune checkpoint inhibitors.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68d41eca713b0b5dfea67575https://doi.org/10.4143/crt.2025.458
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunohistochemistry-based molecular classification using TCGA and ACRG Algorithm in locally advanced and metastatic gastric cancer2025
  2. 2Immune landscape and TAM density in endometrial cancer: implications for immune checkpoint inhibitors efficacy2025
  3. 3Progress of immune checkpoint inhibitors in gastric cancer2025
  4. 4Impact of Adding Immune Checkpoint Inhibitors to Neoadjuvant Chemotherapy on pCR and Tumor Downstaging in Resectable Gastric Cancer: A Meta-Analysis2026
  5. 5Immune Cytolytic Activity Correlates with Tumor Microenvironmental Aberrations in Colorectal Cancer2026