August 12, 2025Experimental Hematology and OncologyOpen Access

In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy

View Full Paper

Ask AI

Bookmark

Authors

MRMaedeh Radandish NMNiloofar Mashhadi AAAmir Hossein Aghayan

Discussion

Member takes

Implication

This review explores how stromal cells influence the function of tertiary lymphoid structures in the tumor microenvironment, suggesting new therapeutic strategies.

Key Points

Tertiary lymphoid structures have a dual role in promoting and inhibiting cancer, revealing a complex interaction in the tumor microenvironment.
TLS presence correlates with improved outcomes and therapeutic response, emphasizing their importance in cancer treatment.
Analysis of stromal components like fibroblasts shows their role in lymphocyte recruitment to TLSs, impacting immune responses.
Targeting TLS maturation and disrupting immunosuppressive environments may enhance immunotherapy effectiveness, warranting further research.

Cite This Study

Radandish et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d647712fa https://doi.org/10.1186/s40164-025-00695-8

View Full Paper

Ask AI

Bookmark

Implication

This review explores how stromal cells influence the function of tertiary lymphoid structures in the tumor microenvironment, suggesting new therapeutic strategies.

In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider