September 10, 2025CellsOpen Access

Tertiary Lymphoid Structures in Human Melanoma: Molecular Mechanisms and Therapeutic Opportunities

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Discussion

This review demonstrates how tertiary lymphoid structures impact tumor microenvironment in melanoma, suggesting new therapeutic opportunities.

Tertiary lymphoid structures in melanoma enhance anti-tumor immune activation, impacting treatment outcomes.
Immunotherapy responses appear improved in melanoma patients with higher levels of tertiary lymphoid structures.
Analysis of TLS involvement utilized genetic signatures and spatial distribution across melanoma subtypes.
Understanding TLS formation mechanisms could indicate disease progression and guide therapeutic strategies.

Ghajar-Rahimi et al. (2025) studied this question.

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This review demonstrates how tertiary lymphoid structures impact tumor microenvironment in melanoma, suggesting new therapeutic opportunities.