July 25, 2025Immunology

Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy

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Authors

XLXinze Li XZXinnan ZhangTianjin University of Traditional Chinese Medicine ZCZhiyong Cao

Discussion

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Implication

Review uncovers how tertiary lymphoid structures influence cancer immunotherapy efficacy, highlighting key cellular interactions and therapeutic strategies.

Key Points

Tertiary lymphoid structures play critical roles in enhancing responses to cancer immunotherapy.
Clinical and preclinical data show heterogeneity of TLSs affects treatment outcomes in cancer patients.
The review details T follicular helper cells' role in antibody production in germinal centres.
Targeting TLSs with specific agents may improve efficacy of immune checkpoint inhibitors in cancer therapy.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce179 https://doi.org/10.1111/imm.70020

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Implication

Review uncovers how tertiary lymphoid structures influence cancer immunotherapy efficacy, highlighting key cellular interactions and therapeutic strategies.