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September 10, 2025Cancer Biology & TherapyOpen Access

Unraveling the dual role of METTL3-mediated m 6 A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications

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Authors

HCHua ChunKBKangzhuo Baima

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Overview

Review highlights METTL3's dual role in bladder cancer progression and potential therapeutic targets.

Key Points

  • METTL3-mediated m6 A RNA modification drives bladder cancer progression and chemoresistance.
  • Overexpression of METTL3 correlates with poor prognosis and contributes to immune evasion in bladder cancer.
  • This review synthesizes key pathways regulated by METTL3, such as HIF1A/IGF2BP3/BIRC5 and AFF4/NF-κB/c-MYC.
  • Targeting METTL3 may enhance the efficacy of existing chemotherapy and immunotherapy treatments.

Cite This Study

Chun et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a28f6https://doi.org/10.1080/15384047.2025.2545057
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