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August 26, 2025

Molecular Profiling of Myeloid Neoplasm by Next-Generation Sequencing

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Authors

RJRam Mohan JaiswalSSShweta SharmaNGNaveen Gupta

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Overview

Integrative analysis identifies mutation patterns in myeloid malignancies using next-generation sequencing.

Key Points

  • Targeted sequencing of 80 genes revealed 23 mutations present in over 5% of patients, indicating significant genetic alterations in myeloid malignancies.
  • Mutational profiles identified specific frequent mutations such as FLT3 and DNMT in acute myeloid leukemia (AML), suggesting unique genetic characteristics of this subtype.
  • Integrative analysis involved 52 patients with myeloid malignancies, demonstrating a clear association between mutations and disease type.
  • Findings highlight the need for further investigation into genetic profiles to improve diagnosis and treatment strategies for patients with myeloid malignancies.

Cite This Study

Jaiswal et al. (2025) studied this question.

synapsesocial.com/papers/68af7f397567bf4f94ff5dddhttps://doi.org/10.38124/ijisrt/25jul795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Next generation sequencing profiling of pediatric Acute Myeloid Leukemia reveals distinct genetic landscapes across cytogenetic subgroups2025
  2. 2Next generation sequencing based genetic landscape and its clinical implications for Egyptian patients with acute myeloid leukemia and Myelodysplastic syndrome2025
  3. 3A Mutational Landscape in Acute Myeloid Leukemia: Overview and Prognostic Impacts2025 · 2 citations
  4. 4Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWP2025
  5. 5A Comprehensive Genomic Analysis of Nucleophosmin (NPM1) in Acute Myeloid Leukemia2025 · 2 citations