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April 1, 2025The Egyptian Journal of Haematology

Next generation sequencing based genetic landscape and its clinical implications for Egyptian patients with acute myeloid leukemia and Myelodysplastic syndrome

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Authors

NANada Ahmed Hamed AbdelRahmanMHMohammed Tarif HamzaGHGehan M. Hamed

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Overview

Cohort study reveals genetic variants in acute myeloid leukemia and myelodysplastic syndrome, indicating significant prognostic implications.

Key Points

  • Presence of genetic variants from NGS is linked to worse clinical outcomes and survival rates.
  • Among 42 patients, AML showed the highest frequency of NGS variants compared to myelodysplastic syndromes.
  • Prospective cohort clinical study utilized Myeloid NGS Oncomine 79-gene panel for genetic mapping in myeloid neoplasms.
  • Understanding genetic alterations provides critical insights for diagnosis, prognosis, and treatment planning in myeloid malignancies.

Cite This Study

AbdelRahman et al. (2025) studied this question.

synapsesocial.com/papers/68af6d847567bf4f94fea6b1https://doi.org/10.4103/ejh.ejh_115_24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integration of Next-Generation Sequencing in Measurable Residual Disease Monitoring in Acute Myeloid Leukemia and Myelodysplastic Neoplasm2025 · 5 citations
  2. 2A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia2025 · 2 citations
  3. 3Next generation sequencing profiling of pediatric Acute Myeloid Leukemia reveals distinct genetic landscapes across cytogenetic subgroups2025
  4. 4Molecular Profiling of Myeloid Neoplasm by Next-Generation Sequencing2025
  5. 5Challenges in accuracy in molecular genetic diagnosis of childhood AML: case series2025