December 4, 2025Advanced ScienceOpen Access

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

View Full Paper

Ask AI

Bookmark

Morphine-induced hyperlocomotion decreased with Cg-ZIm pathway inhibition, supporting the role of Delta Opioid Receptors.
Evidence emerged from high-dose morphine (10-15mg kg−1), revealing dual effects on hyperactivity and analgesia.
Research involved chemogenetic methods targeting the excitatory projection from the cingulate cortex to zona incerta.
Findings suggest potential for optimizing clinical outcomes by targeting neural circuits underlying opioid effects.

Discussion

No takes yet. Share an insight, caveat, or question.

Chemogenetic inhibition reduced morphine-induced hyperactivity in mice, indicating pathways for better clinical outcomes.

Shen et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark