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August 26, 2025Hepatology CommunicationsOpen Access

Unifying FALD assessment—A call to arms

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Authors

JCJacob CaoRCRachael CordinaAMAvik Majumdar

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Overview

Systematic review highlights diagnostic limitations in fibrosis assessment for Fontan-associated liver disease, suggesting uniform methodologies are crucial.

Key Points

  • Improved risk stratification for fontan-associated liver disease can enhance patient management and outcomes.
  • Noninvasive factors linked to severe fibrosis include time since fontan completion and platelet count, as outlined in the systematic review.
  • Assessing fibrosis through liver biopsy faces criticisms, including patchy hepatocellular damage, leading to potential misclassification of patients.
  • Highlighting the complexities in defining and evaluating fibrosis underscores the urgent need for consistent diagnostic criteria across studies.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68af7df87567bf4f94ff5280https://doi.org/10.1097/hc9.0000000000000789
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reply: Unifying FALD assessment—A call to arms2025
  2. 2Non-invasive fibrosis tools lack clinical utility for identifying advanced fibrosis in Fontan-associated liver disease: a retrospective cohort study2025 · 3 citations
  3. 3Fontan-Associated Liver Disease2025
  4. 4Efficacy of Magnetic Resonance Elastography in Fontan‐Associated Liver Disease2025 · 3 citations
  5. 5Abstract Wed159: Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan-Associated Liver Disease2025