Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025BMJ Open GastroenterologyOpen Access

Non-invasive fibrosis tools lack clinical utility for identifying advanced fibrosis in Fontan-associated liver disease: a retrospective cohort study

View Full Paper
Ask AI
Bookmark
Share

Authors

PAPaul ArmstrongAMAoife MoriartyRHRobert Hughes

Discussion

Loading...

Member takes

Overview

Retrospective cohort study assesses advanced fibrosis in adult Fontan patients, suggesting limited NIT utility.

Key Points

  • The study finds a high prevalence of advanced liver fibrosis among Fontan patients in their third decade.
  • Liver stiffness measurement showed a weak correlation with advanced fibrosis, with an area under the curve of 0.65.
  • Patients with a closed Fontan fenestration had higher rates of advanced fibrosis, indicating a potential risk factor.
  • Despite non-invasive tools, liver biopsy remains essential for accurate diagnosis of advanced fibrosis.

Cite This Study

Armstrong et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479fa63https://doi.org/10.1136/bmjgast-2024-001733
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unifying FALD assessment—A call to arms2025
  2. 2Reply: Unifying FALD assessment—A call to arms2025
  3. 3Revisiting Hepatic Fibrosis Risk in Congenital Heart Disease: Insights from Non-Invasive Markers and Echocardiography2025
  4. 4Fontan‐Associated Liver Disease: Trends Over Time and Relationship With Outcomes2025
  5. 5Evaluation of Liver Fibrosis Using Non-invasive Indices in the Bandar Kong Cohort Population, Hormozgan-Iran, During 2016–20182025