Multiomic study uncovers metabolic reprogramming in liver fibrosis among adolescents with Fontan circulation, indicating disease mechanisms.
Key Points
Significant metabolic abnormalities were discovered in the livers of adolescent patients with Fontan circulation, particularly in amino acid metabolism.
Results showed that liver metabolic reprogramming contributes to circulatory metabolomic changes in Fontan-associated liver disease.
Single-nucleus multiomic RNA sequencing and assays unveiled potential underlying mechanisms of metabolic alterations in FALD.
Comparing data with metabolic dysfunction-associated fatty liver disease highlighted dysregulated amino acid metabolism as a common issue.