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September 12, 2025CancersOpen Access

The Underlying Mechanisms and Emerging Strategies to Overcome Resistance in Breast Cancer

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Authors

KKKrishnaswamy KannanASAlagarsamy SrinivasanAKAarthi Kannan

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Overview

Review synthesizes resistance mechanisms in breast cancer, highlighting tumor microenvironment and immune evasion.

Key Points

  • Resistance in breast cancer leads to poor outcomes due to drug efflux and altered signaling pathways.
  • Genetic mutations and cancer stem cell plasticity contribute significantly to therapeutic resistance and evasion.
  • The review unifies the understanding of breast cancer resistance, focusing on regulated cell death pathways and metabolic shifts.
  • Artificial intelligence enhances resistance biology understanding, assisting in early detection and patient stratification.

Cite This Study

Kannan et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee7713b0b5dfea682fchttps://doi.org/10.3390/cancers17172938
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Also Consider

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  1. 1The Underlying Mechanisms and Emerging Strategies to Overcome Resistance in Breast Cancer2025 · 7 citations
  2. 2Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies2025
  3. 3Breast Cancer: Molecular Pathogenesis and Targeted Therapy2025 · 14 citations
  4. 4Resistance to neoadjuvant chemotherapy in breast cancers: a metabolic perspective2025
  5. 5Mechanism of Chemotherapy Resistance: a Comprehensive Review2025 · 1 citations