Longitudinal metabolic trajectories in Diabetes Prevention Program participants reveal subgroups with varying micro and macrovascular complication risks
Longitudinal analysis identifies distinct prediabetes subgroups linked to varying micro and macrovascular risks.
Key Points
Two-thirds of prediabetes participants maintained stable glycemia, indicating metabolic resilience and low complication risk.
Cluster 3 participants exhibited a steep rise in insulin resistance, with 92% developing type 2 diabetes and a higher incidence of retinopathy and neuropathy.
Observational analysis across long-term data of 1,732 individuals reveals four distinct metabolic subgroups with varying risks.
Implications highlight the need for targeted interventions to prevent complications, especially in those with early microalbuminuria.