January 1, 2025

Physiological Dysregulations Associated with Hepatitis E Virus Infection in Pregnant Women: An Analytical Study of Pathogenic Mechanisms and Elevated Maternal Mortality Risk

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Analytical study finds elevated maternal mortality risk in HEV-infected pregnant women, indicating immune and hormonal dysfunctions.

Elevated maternal mortality risk associated with hepatitis E virus infection impacts pregnant women.
Cytokine profiles showed significant changes, including increased TNF-α and altered regulatory T cells in patients.
Case-control study compared 77 HEV-infected pregnant women to 77 healthy controls, revealing crucial pathogenic mechanisms.
Findings highlight the need for monitoring immune and hormonal parameters during pregnancy in HEV cases.

Saleh et al. (2025) studied this question.

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