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August 23, 2025CancersOpen Access

Immune System–Tumor Crosstalk Under Microgravity: Mechanistic Insights, Challenges, and Translational Perspectives

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Authors

SJSeyedesomaye JasemiESElena Rita SimulaYLYao Lin

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Overview

Review reveals how microgravity affects tumor growth and immune responses in cancer therapy, suggesting new immunotherapeutic strategies.

Key Points

  • Microgravity alters immune regulation, complicating cancer treatment by promoting immune evasion and tumor progression.
  • Key findings show that microgravity can enhance immune dysregulation, potentially worsening treatment efficacy and resistance to therapies.
  • Analysis discusses oncogenic signaling pathways affected by microgravity, like NF-κB and ERK1/2, highlighting significant cellular transformations.
  • Insights from microgravity research offer translational potential for developing better cancer treatment strategies on Earth and in space.

Cite This Study

Jasemi et al. (2025) studied this question.

synapsesocial.com/papers/68af7b127567bf4f94ff230chttps://doi.org/10.3390/cancers17172737
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