September 18, 2025Frontiers in ImmunologyOpen Access

Microbial metabolites and their influence on the tumor microenvironment

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Microbial metabolites shape the tumor immune microenvironment and influence immunotherapeutic efficacy.
Key metabolites include short-chain fatty acids, bile acids, and lipopolysaccharides, affecting immune cell metabolism.
The human commensal microbiome acts as a 'second genome', playing a central role in tumor immunometabolism.
Metabolic reprogramming of immune cells is crucial for understanding tumor immune evasion and therapeutic resistance.

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This review reveals how microbial metabolites modulate tumor immunity and metabolic pathways, impacting immunotherapy efficacy.

Duan et al. (2025) studied this question.

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