Intramolecular Hetero‐Cyclization of Novel Indole‐Substituted Nitrogen‐Bridged Pyrimidine and Thiazole Derivatives: A Mechanistic Insight and In Vitro Cytotoxic Evaluation

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In vitro evaluation highlights cytotoxic effects of novel pyrimidine and thiazole derivatives against A549 cells, suggesting new synthesis pathways.

Compounds showed anticancer efficacy, with 3a being the most cytotoxic at an IC 50 of 5.988 µM.
The study utilized innovative synthetic methods to create diverse indole-substituted heterocycles.
Intramolecular cyclization pathways were explored, leading to good yields (51%-83%) of the synthesized compounds.
Evaluation involved advanced structural validation techniques like FTIR, NMR, and HRMS for confirmation.

Anjirwala et al. (2025) studied this question.

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In vitro evaluation highlights cytotoxic effects of novel pyrimidine and thiazole derivatives against A549 cells, suggesting new synthesis pathways.