Functionalized Indolizines as Potential Anticancer Agents: Synthetic, Biological and In Silico Investigations

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Discussion

Synthesis and biological assessment of indolizines revealed promising anticancer activity, indicating potential as drug candidates.

Three new series of indolizines were synthesized, showing promising anticancer activity against several tumor cell lines.
Compounds 5c, 6c, and 7g demonstrated notable inhibition on human cancer cells, particularly lung and glioblastoma.
Molecular docking suggested favorable binding at the colchicine-binding site of tubulin, with significant affinities identified.
The ADMET analysis predicted good bioavailability and low toxicity risks for the active indolizine derivatives.

Ciorteanu et al. (2025) studied this question.

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