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August 1, 2025

Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications.

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Authors

ZZZhen ZhangSLShuai LiJSJianjun Sun

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Overview

Meta-analysis demonstrates varying effectiveness of silymarin, Mediterranean diets, and lifestyle modifications for reducing liver disease markers.

Key Points

  • Silymarin combined with Mediterranean diets reduced total cholesterol by 0.39 SMD, suggesting dietary changes can aid liver health.
  • Triglyceride levels decreased significantly with silymarin+medication, indicating effective treatment options for NAFLD.
  • Combination treatments led to substantial reductions in alanine aminotransferase, highlighting the role of lifestyle modifications.
  • Silymarin showed a notable increase in adverse effects, emphasizing the need for careful monitoring during treatment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd96https://doi.org/10.6133/apjcn.202508_34(4).0003
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