Pathological and Immunophenotypic Assessment of Canine Splenic Lymphoma in Biopsy and Necropsy Cases

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Observational analysis reveals high-grade B-cell lymphoma in canine splenic cases, indicating the importance of immunophenotyping.

High-grade B-cell lymphoma was found in all cases of canine splenic lymphoma, signaling its clinical importance.
Eight canine cases were evaluated, with six diagnosed as multicentric diffuse large B-cell lymphomas and two as primary splenic lymphomas.
Cytological and histopathological evaluations followed WHO criteria, showing significant structural changes in the spleen tissue.
Integration of various diagnostic methods enhances accurate subtyping of lymphoma and serves as a guideline for veterinary practice.

Mohanapriya et al. (2025) studied this question.

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