Does Ideal Blood Pressure Vary by Cognitive Domain? A UK Biobank Study

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Higher baseline systolic blood pressure relates nonlinearly to cognitive functions, with ideal values differing for each domain, like fluid intelligence, attention, and reaction time.
Significant ideal systolic blood pressure levels are found for fluid intelligence (118 mmHg), attention (127.5 mmHg), and reaction time (150.5 mmHg), indicating varying impacts.
The study utilized nonlinear mixed-effects regression models, assessing over 439,301 participants, including interactions with age, sex, and hypertension history.
Older and untreated hypertensive individuals exhibit poorer cognitive performance, emphasizing the importance of maintaining optimal blood pressure levels.

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Analysis of nonlinear relationships between blood pressure and cognitive performance in a large cohort, suggesting variations by cognitive domain.

Lennon et al. (2025) studied this question.

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Analysis of nonlinear relationships between blood pressure and cognitive performance in a large cohort, suggesting variations by cognitive domain.