August 14, 2025The Journal of Prevention of Alzheimer s DiseaseOpen Access

Blood pressure and Alzheimer’s disease biomarkers in cognitively unimpaired adults: a multicenter study

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Elevated blood pressure was associated with increased Aβ PET accumulation in cognitively unimpaired individuals.
In EPAD, diastolic blood pressure negatively correlated with CSF Aβ42 (p < 0.001), highlighting its influence on Alzheimer's pathology.
Observational analysis across three multicenter studies revealed significant effects of blood pressure on Alzheimer's disease biomarkers over time.
Findings suggest further research is needed to explore mechanisms behind the negative associations between blood pressure and cerebrospinal fluid biomarkers.

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Implication

Cross-sectional analysis shows blood pressure impacts Alzheimer's biomarkers in cognitively unimpaired adults, indicating potential risk factors for dementia.

Cite This Study

Osset-Malla et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d64771998 https://doi.org/10.1016/j.tjpad.2025.100304

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Implication

Cross-sectional analysis shows blood pressure impacts Alzheimer's biomarkers in cognitively unimpaired adults, indicating potential risk factors for dementia.

Blood pressure and Alzheimer’s disease biomarkers in cognitively unimpaired adults: a multicenter study

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Discussion

Implication

Cite This Study

Blood pressure and Alzheimer’s disease biomarkers in cognitively unimpaired adults: a multicenter study

Key Points

Discussion

Implication

Cite This Study

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