Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characterize sepsis?

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Distinct gut microbiota profiles were observed between sepsis and non-sepsis patients during early antibiotic therapy.
Alpha diversity was significantly lower in sepsis patients at 2.48 compared to 3.0 in non-sepsis patients, with p = 0.01.
Taxonomic profiling showed decreased Anaerobutyricum spp. and increased Holdemania spp. in the sepsis group early in treatment.
Findings suggest microbiota-based strategies may guide antibiotic therapy and improve outcomes for critically ill patients.

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Amplicon sequencing reveals distinct gut microbiota in sepsis patients, indicating potential biomarkers for treatment.

Guerra et al. (2025) studied this question.

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