Higher abundance of Faecalibacterium prausnitzii in the gut microbiome is associated with a lower risk of sepsis development among 6,372 individuals followed for 20 years
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Key Points
This research aims to determine if gut microbiome composition can predict long-term sepsis risk in the general population.
Analyzed data from 6,372 individuals followed for 19.8 years
Used fecal sampling and multivariable-adjusted models to assess microbial diversity and species associations
Conducted validation in an independent cohort of 4,248 individuals
A 1-SD increase in Faecalibacterium prausnitzii abundance linked to a 21% lower risk of sepsis (95% CI, 10%-30%; FDR = 0.03)
Six other species were positively associated with increased sepsis risk, correlating with C-reactive protein
Findings were consistent across subgroups and in an independent cohort
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Implication
Randomized trial identifies gut microbiome's role in sepsis risk among adults, suggesting protective benefits of certain species.