Narrative review on microbiota and sepsis: the host’s betrayal?

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Dysbiosis contributes to systemic inflammation and immune dysfunction in sepsis, emphasizing its role as an active driver.
Key biomarkers like diamine oxidase are emerging as important indicators of gut injury during septic progression.
Assessment using multi-omics and bioinformatics can stratify septic patients based on microbiota signatures.
Modulating gut microbiota represents a novel therapeutic frontier, calling for innovative research designs to improve patient outcomes.

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Narrative review highlights the role of gut microbiota and biomarkers in sepsis progression, indicating novel therapeutic strategies.

Guarino et al. (2025) studied this question.

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