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October 1, 2025NutrientsOpen Access

Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions

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Authors

BCBaorong ChenKLK. LiXWXiaodan Wang

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Overview

Study reveals variations in antimicrobial peptides in human milk across lactation and Chinese regions, indicating dietary influences.

Key Points

  • Milk from 200 mothers showed dynamic changes in peptide profiles across lactation stages and regions.
  • A total of 6960 peptides from 621 proteins were identified, with higher PIGR levels in the 2nd month enhancing infant immunity.
  • Samples were analyzed using LC-MS/MS, revealing significant regional differences, particularly in Lanzhou's β-casein peptides.
  • Maternal oil and fat intake correlated with specific antimicrobial peptides, influencing infant growth and health outcomes.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc499062https://doi.org/10.3390/nu17193131
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Also Consider

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  1. 1Influence of Gestational Age on the Level of Functional Peptides (Peptidome) in Breast Milk2025
  2. 2Unraveling Stage-Specific Metabolites in Human Milk and Their Links to Maternal Physiology: Insights from a Mexican Population2025
  3. 3Composition of the human milk microbiome in the GUSTO cohort is shaped by intrapartum antibiotic prophylaxis and breastfeeding exclusivity2025 · 4 citations
  4. 4Characterization of Omics Components in Human Milk: A Systematic Review.2025
  5. 5Longitudinal Profiling of the Human Milk Microbiome from Birth to 12 Months Reveals Overall Stability and Selective Taxa-Level Variation2025 · 4 citations